small molecules prestwick chemical library Search Results


small molecules prestwick chemical library  (Prestwick Chemical)
90
Prestwick Chemical small molecules prestwick chemical library
Small Molecules Prestwick Chemical Library, supplied by Prestwick Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
small molecules prestwick chemical library - by Bioz Stars, 2026-04
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small molecules  (Prestwick Chemical)
90
Prestwick Chemical small molecules
Visual Summary: Plasma fibrinogen concentration correlates with CVD event risk and high fibrinogen levels are considered prothrombotic. A chemical library of <t>bioactive</t> compounds was screened for altering fibrinogen production. Active compounds were identified by a broad screen in HepG2 cells and then by a series of selection steps in cellular models and zebrafish larvae. Anthralin treatment led to lower fibrinogen production, whereas all- trans retinoic acid increased it. Using laser-induced venous thrombosis assays in zebrafish larvae, anthralin showed antithrombotic activity whereas all- trans retinoic acid was prothrombotic (created with BioRender.com).
Small Molecules, supplied by Prestwick Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/small molecules/product/Prestwick Chemical
Average 90 stars, based on 1 article reviews
small molecules - by Bioz Stars, 2026-04
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small-molecule libraries  (Prestwick Chemical)
90
Prestwick Chemical small-molecule libraries
Visual Summary: Plasma fibrinogen concentration correlates with CVD event risk and high fibrinogen levels are considered prothrombotic. A chemical library of <t>bioactive</t> compounds was screened for altering fibrinogen production. Active compounds were identified by a broad screen in HepG2 cells and then by a series of selection steps in cellular models and zebrafish larvae. Anthralin treatment led to lower fibrinogen production, whereas all- trans retinoic acid increased it. Using laser-induced venous thrombosis assays in zebrafish larvae, anthralin showed antithrombotic activity whereas all- trans retinoic acid was prothrombotic (created with BioRender.com).
Small Molecule Libraries, supplied by Prestwick Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/small-molecule libraries/product/Prestwick Chemical
Average 90 stars, based on 1 article reviews
small-molecule libraries - by Bioz Stars, 2026-04
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library consisting of 1280 chemically diverse small molecules  (Prestwick Chemical)
90
Prestwick Chemical library consisting of 1280 chemically diverse small molecules
Visual Summary: Plasma fibrinogen concentration correlates with CVD event risk and high fibrinogen levels are considered prothrombotic. A chemical library of <t>bioactive</t> compounds was screened for altering fibrinogen production. Active compounds were identified by a broad screen in HepG2 cells and then by a series of selection steps in cellular models and zebrafish larvae. Anthralin treatment led to lower fibrinogen production, whereas all- trans retinoic acid increased it. Using laser-induced venous thrombosis assays in zebrafish larvae, anthralin showed antithrombotic activity whereas all- trans retinoic acid was prothrombotic (created with BioRender.com).
Library Consisting Of 1280 Chemically Diverse Small Molecules, supplied by Prestwick Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/library consisting of 1280 chemically diverse small molecules/product/Prestwick Chemical
Average 90 stars, based on 1 article reviews
library consisting of 1280 chemically diverse small molecules - by Bioz Stars, 2026-04
90/100 stars
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library of off-patent and biologically active molecules  (Prestwick Chemical)
90
Prestwick Chemical library of off-patent and biologically active molecules
Visual Summary: Plasma fibrinogen concentration correlates with CVD event risk and high fibrinogen levels are considered prothrombotic. A chemical library of <t>bioactive</t> compounds was screened for altering fibrinogen production. Active compounds were identified by a broad screen in HepG2 cells and then by a series of selection steps in cellular models and zebrafish larvae. Anthralin treatment led to lower fibrinogen production, whereas all- trans retinoic acid increased it. Using laser-induced venous thrombosis assays in zebrafish larvae, anthralin showed antithrombotic activity whereas all- trans retinoic acid was prothrombotic (created with BioRender.com).
Library Of Off Patent And Biologically Active Molecules, supplied by Prestwick Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/library of off-patent and biologically active molecules/product/Prestwick Chemical
Average 90 stars, based on 1 article reviews
library of off-patent and biologically active molecules - by Bioz Stars, 2026-04
90/100 stars
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chemical library molecules  (Prestwick Chemical)
90
Prestwick Chemical chemical library molecules
Visual Summary: Plasma fibrinogen concentration correlates with CVD event risk and high fibrinogen levels are considered prothrombotic. A chemical library of <t>bioactive</t> compounds was screened for altering fibrinogen production. Active compounds were identified by a broad screen in HepG2 cells and then by a series of selection steps in cellular models and zebrafish larvae. Anthralin treatment led to lower fibrinogen production, whereas all- trans retinoic acid increased it. Using laser-induced venous thrombosis assays in zebrafish larvae, anthralin showed antithrombotic activity whereas all- trans retinoic acid was prothrombotic (created with BioRender.com).
Chemical Library Molecules, supplied by Prestwick Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/chemical library molecules/product/Prestwick Chemical
Average 90 stars, based on 1 article reviews
chemical library molecules - by Bioz Stars, 2026-04
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chemical library of 1271 small molecules  (Prestwick Chemical)
90
Prestwick Chemical chemical library of 1271 small molecules
Visual Summary: Plasma fibrinogen concentration correlates with CVD event risk and high fibrinogen levels are considered prothrombotic. A chemical library of <t>bioactive</t> compounds was screened for altering fibrinogen production. Active compounds were identified by a broad screen in HepG2 cells and then by a series of selection steps in cellular models and zebrafish larvae. Anthralin treatment led to lower fibrinogen production, whereas all- trans retinoic acid increased it. Using laser-induced venous thrombosis assays in zebrafish larvae, anthralin showed antithrombotic activity whereas all- trans retinoic acid was prothrombotic (created with BioRender.com).
Chemical Library Of 1271 Small Molecules, supplied by Prestwick Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/chemical library of 1271 small molecules/product/Prestwick Chemical
Average 90 stars, based on 1 article reviews
chemical library of 1271 small molecules - by Bioz Stars, 2026-04
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small molecules 2012 collection  (Prestwick Chemical)
90
Prestwick Chemical small molecules 2012 collection
(A) Screening of the Prestwick chemical library containing <t>1200</t> marketed drugs at 20 μM (green round circles) showing specific hits (red round circles) and non-specific hits (triangles). 2-deoxy-D-glucose at 0.5 mM was used as a positive control. (B) Hit validation assay showing that the four drugs were authentic hits because they were ineffective on G6PDH used in <t>the</t> <t>CpHK/G6PDH-coupled</t> assay. Bars represent standard errors of the mean (SEMs) derived from at least three replicated reactions.
Small Molecules 2012 Collection, supplied by Prestwick Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/small molecules 2012 collection/product/Prestwick Chemical
Average 90 stars, based on 1 article reviews
small molecules 2012 collection - by Bioz Stars, 2026-04
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small molecules dissolved in me 2 so  (Prestwick Chemical)
90
Prestwick Chemical small molecules dissolved in me 2 so
(A) Screening of the Prestwick chemical library containing <t>1200</t> marketed drugs at 20 μM (green round circles) showing specific hits (red round circles) and non-specific hits (triangles). 2-deoxy-D-glucose at 0.5 mM was used as a positive control. (B) Hit validation assay showing that the four drugs were authentic hits because they were ineffective on G6PDH used in <t>the</t> <t>CpHK/G6PDH-coupled</t> assay. Bars represent standard errors of the mean (SEMs) derived from at least three replicated reactions.
Small Molecules Dissolved In Me 2 So, supplied by Prestwick Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/small molecules dissolved in me 2 so/product/Prestwick Chemical
Average 90 stars, based on 1 article reviews
small molecules dissolved in me 2 so - by Bioz Stars, 2026-04
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1200 fda-approved small molecules  (Prestwick Chemical)
90
Prestwick Chemical 1200 fda-approved small molecules
(A) Screening of the Prestwick chemical library containing <t>1200</t> marketed drugs at 20 μM (green round circles) showing specific hits (red round circles) and non-specific hits (triangles). 2-deoxy-D-glucose at 0.5 mM was used as a positive control. (B) Hit validation assay showing that the four drugs were authentic hits because they were ineffective on G6PDH used in <t>the</t> <t>CpHK/G6PDH-coupled</t> assay. Bars represent standard errors of the mean (SEMs) derived from at least three replicated reactions.
1200 Fda Approved Small Molecules, supplied by Prestwick Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/1200 fda-approved small molecules/product/Prestwick Chemical
Average 90 stars, based on 1 article reviews
1200 fda-approved small molecules - by Bioz Stars, 2026-04
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molecules from the in-silico library  (Prestwick Chemical)
90
Prestwick Chemical molecules from the in-silico library
(A) Screening of the Prestwick chemical library containing <t>1200</t> marketed drugs at 20 μM (green round circles) showing specific hits (red round circles) and non-specific hits (triangles). 2-deoxy-D-glucose at 0.5 mM was used as a positive control. (B) Hit validation assay showing that the four drugs were authentic hits because they were ineffective on G6PDH used in <t>the</t> <t>CpHK/G6PDH-coupled</t> assay. Bars represent standard errors of the mean (SEMs) derived from at least three replicated reactions.
Molecules From The In Silico Library, supplied by Prestwick Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/molecules from the in-silico library/product/Prestwick Chemical
Average 90 stars, based on 1 article reviews
molecules from the in-silico library - by Bioz Stars, 2026-04
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library of ~30,000 small molecules  (Prestwick Chemical)
90
Prestwick Chemical library of ~30,000 small molecules
(A) Screening of the Prestwick chemical library containing <t>1200</t> marketed drugs at 20 μM (green round circles) showing specific hits (red round circles) and non-specific hits (triangles). 2-deoxy-D-glucose at 0.5 mM was used as a positive control. (B) Hit validation assay showing that the four drugs were authentic hits because they were ineffective on G6PDH used in <t>the</t> <t>CpHK/G6PDH-coupled</t> assay. Bars represent standard errors of the mean (SEMs) derived from at least three replicated reactions.
Library Of ~30,000 Small Molecules, supplied by Prestwick Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/library of ~30,000 small molecules/product/Prestwick Chemical
Average 90 stars, based on 1 article reviews
library of ~30,000 small molecules - by Bioz Stars, 2026-04
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Image Search Results


Visual Summary: Plasma fibrinogen concentration correlates with CVD event risk and high fibrinogen levels are considered prothrombotic. A chemical library of bioactive compounds was screened for altering fibrinogen production. Active compounds were identified by a broad screen in HepG2 cells and then by a series of selection steps in cellular models and zebrafish larvae. Anthralin treatment led to lower fibrinogen production, whereas all- trans retinoic acid increased it. Using laser-induced venous thrombosis assays in zebrafish larvae, anthralin showed antithrombotic activity whereas all- trans retinoic acid was prothrombotic (created with BioRender.com).

Journal: Thrombosis and Haemostasis

Article Title: Chemical Modulators of Fibrinogen Production and Their Impact on Venous Thrombosis

doi: 10.1055/s-0040-1718414

Figure Lengend Snippet: Visual Summary: Plasma fibrinogen concentration correlates with CVD event risk and high fibrinogen levels are considered prothrombotic. A chemical library of bioactive compounds was screened for altering fibrinogen production. Active compounds were identified by a broad screen in HepG2 cells and then by a series of selection steps in cellular models and zebrafish larvae. Anthralin treatment led to lower fibrinogen production, whereas all- trans retinoic acid increased it. Using laser-induced venous thrombosis assays in zebrafish larvae, anthralin showed antithrombotic activity whereas all- trans retinoic acid was prothrombotic (created with BioRender.com).

Article Snippet: Small Molecules The Prestwick Chemical Library (Prestwick Chemical, Illkirch, France), comprising 1,280 bioactive small molecules in 96-well plates, was screened for compounds that alter fibrinogen production.

Techniques: Clinical Proteomics, Concentration Assay, Selection, Activity Assay

(A) Screening of the Prestwick chemical library containing 1200 marketed drugs at 20 μM (green round circles) showing specific hits (red round circles) and non-specific hits (triangles). 2-deoxy-D-glucose at 0.5 mM was used as a positive control. (B) Hit validation assay showing that the four drugs were authentic hits because they were ineffective on G6PDH used in the CpHK/G6PDH-coupled assay. Bars represent standard errors of the mean (SEMs) derived from at least three replicated reactions.

Journal: The Journal of eukaryotic microbiology

Article Title: The Action of the Hexokinase Inhibitor 2-deoxy-D-glucose on Cryptosporidium parvum and the Discovery of Activities against the Parasite Hexokinase from Marketed Drugs

doi: 10.1111/jeu.12690

Figure Lengend Snippet: (A) Screening of the Prestwick chemical library containing 1200 marketed drugs at 20 μM (green round circles) showing specific hits (red round circles) and non-specific hits (triangles). 2-deoxy-D-glucose at 0.5 mM was used as a positive control. (B) Hit validation assay showing that the four drugs were authentic hits because they were ineffective on G6PDH used in the CpHK/G6PDH-coupled assay. Bars represent standard errors of the mean (SEMs) derived from at least three replicated reactions.

Article Snippet: Four existing drugs were discovered to possess anti-CpHK activities As a first step to discover new CpHK inhibitors, we screened 1200 small molecules (2012 collection) in the Prestwick Chemical Library using an HK/G6PDH-coupled assay.

Techniques: Positive Control, Biomarker Discovery, Derivative Assay

Inhibition of the CpHK and HsHK1 enzyme activity by the top four hits identified from 1200 existing drugs and their efficacies against the growth of C. parvum in vitro

Journal: The Journal of eukaryotic microbiology

Article Title: The Action of the Hexokinase Inhibitor 2-deoxy-D-glucose on Cryptosporidium parvum and the Discovery of Activities against the Parasite Hexokinase from Marketed Drugs

doi: 10.1111/jeu.12690

Figure Lengend Snippet: Inhibition of the CpHK and HsHK1 enzyme activity by the top four hits identified from 1200 existing drugs and their efficacies against the growth of C. parvum in vitro

Article Snippet: Four existing drugs were discovered to possess anti-CpHK activities As a first step to discover new CpHK inhibitors, we screened 1200 small molecules (2012 collection) in the Prestwick Chemical Library using an HK/G6PDH-coupled assay.

Techniques: Inhibition, Activity Assay